PDB rosmol

PROTEIN DATABASE

• it is the archive of experimentally determined three dimensional structure of biological macro molecules that serves a global community of researchers, educators and students. 
• the data obtained by X-ray crystallography or NMR spectroscopy and submitted by researchers to this website.
• the website is known as Protein Data Bank.
• it act as important resource for research in academic, pharmaceutical and biotechnology sectors.

 RASMOL

• it is computer program written for interactive molecular graphics visualization intended and used primarily for the depiction and exploration of biological macromolecules structures.
• it is used in Protein Data Bank 
• it reads in the 3-D coordinates for a molecule using pdf file format
• it allow one to rotate the molecule interactively

below are several type of enzymes with their structure and description.

 RENIN

Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring

CLASSIFICATION               : HYDROLASE
STRUCTURE WEIGHT         : 74547.03
MOLECULE                      : RENIN
POLYMER                        : 1
TYPE                               :  PROTEIN
LENGTH                          : 333
CHAINS                           : A, B
ORGANISM                      : HOMOSAPIEN

HTR A

HTR-like protein from Haloarcula marismortui

CLASSIFICATION               : TRANSFERASE
STRUCTURE WEIGHT         : 60054.17
MOLECULE                      : HTR A
POLYMER                        : 1
TYPE                               :  PROTEIN
LENGTH                           : 126
CHAINS                           : A, B, C, D
ORGANISM                      : HALOARCULA MARISMORTUI ATCC 43049

FRAGMENT PAS DOMAIN : RESIDUE 387 - 509

SUBTILISIN

What is the meaning of this things???Let's explore about that now...yeaayyyy...There are many types of subtilisin enzyme,but today we only focused on 4C3U subtilisin.

For 4C3U,the discription of this molecular can be summarise as follow:

CLASSIFICATION          : HYDROLASE
STRUCTURE WEIGHT     : 28911.24
MOLECULE                  : SUBTILISIN CARLSBERG
POLYMER                    : 1
TYPE                           : PROTEIN
LENGTH                      : 274

CHAINS                       : A

EC#                           : 3.4.21.62

ORGANISM                  : BACCILUS LICHENIFORMIS

DEGQ

Now,we proceed to the  next enzyme which is DegQ.We choose 3PV5 DegQ to describe in this blog.

The detail about enzyme 3PV5 can be summarise as follow :

CLASSIFICATION                 : HYDROLASE

STRUCTURE WEIGHT            : 191744.00

MOLECULE                         : DegQ

POLYMER                           : 1

TYPE                                  : PROTEIN

LENGTH                              : 451

MUTATION                           : N189G, P190G

ORGANISM                          : LEGIONELLA FALLONII

THERMOLYSIN

Our last enzyme for today is thermolysin 1KJO.Let's explore about this.

Same with previous structure,thermolysin 1KJO also have its own description. 

CLASSIFICATION              : HYDROLASE/HYDROLASE INHIBATOR

STRUCTURE WEIGHT        : 34876.02

MOLECULE                     : THERMOLYSIN

POLYMER                       : 1

TYPE                             : PROTEIN

LENGTH                         : 316

EC#                              : 3.4.24.27

ORGANISM                     : BACILLUS THERMOPROTEOLYTICUS

GENE NAME                    : NPR